There is no known cause of Non-Alcoholic Fatty Liver yet. There are certain studies that suggest that NAFLD is linked to certain factors.
NAFLD and NASH are both linked to overweight or obesity, insulin resistance (a condition in which your cells don’t take up sugar in response to insulin), high blood sugar (hyperglycemia), and high levels of fats, particularly triglycerides, in the blood. All of these promote deposit of fat in the liver. For some people, this excess fat acts as a toxin to liver cells, causing liver inflammation and NASH, which may lead to a buildup of scar tissue in the liver. Similarly, a number of rare disorders of lipid metabolism have been associated with the development of NAFLD.
According to studies, few medications have been associated with NAFLD such as HAART ( antiretroviral therapies to treat HIV disease), Methotrexate, Corticosteroids, Tamoxifen, etc. Some uncommon factors which might lead to NAFLD are total parenteral nutrition, hepatitis C infection, environmental toxicity, severe surgical weight loss, Wilson’s disease, celiac disease, and starvation.
Other risk factors include disruption in your microbiome (your gut), polycystic ovary syndrome, sleep apnea, underactive thyroid (hypothyroidism), and underactive pituitary gland (hypopituitarism).
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