Is there any correlation between Cancer and PCOS (Polycystic Ovary Syndrome)?



Yes. There is a possible correlation between PCOS (Polycystic Ovary Syndrome) and endometrial cancer, which emerges from clinical trials or research focused on molecular changes in endometrium patients with PCOS (Polycystic Ovary Syndrome). However, the correlation between PCOS and breast or ovarian cancer is still being studied. There is no meta-analysis focused on this correlation to find a conclusive result.

Studies state that women with PCOS (Polycystic Ovary Syndrome) have a 2.7-fold increased risk for developing endometrial cancer. A major factor for this increased malignancy risk is prolonged exposure of the endometrium to unopposed estrogen that results from anovulation {the lack or absence of ovulation (the release of an egg)}. 

Similar results were found in another research stating that long and irregular menstrual cycles, a hallmark of PCOS (Polycystic Ovary Syndrome), have been associated with higher androgen and lower sex hormone-binding globulin levels and this altered hormonal environment may increase the risk of specific subtypes of ovarian cancer. 

An increased risk of ovarian cancer may also exist in some women with PCOS. The data from another research suggests that the hormonal status of women with PCOS featuring abnormal patterns of gonadotropin secretion (enhanced levels of LH) in lean women may be a mitigating factor for the observed association between PCOS and ovarian cancer. 

There is no apparent association of PCOS with breast cancer, although the high prevalence of metabolic dysfunction from obesity is a common denominator for both conditions.

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Disclaimer
Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can further read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

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