AMU faculty makes breakthrough in cancer prevention

Just In

Last Updated on May 3, 2023 by Team THIP

Aligarh, May 3 (IANS) In a major breakthrough in the field of cancer prevention, a common mechanism has been discovered that activates disruption of a single RNA binding protein, MSI-2 binding to mRNAs of the cancer-causing proteins and significantly reduces the synthesis and accumulation of these proteins, reducing HCV infection and proliferation.

Hifzur Rahman Siddique of Department of Zoology, Aligarh Muslim University (AMU), in coordination with Dr. Keigo Machida, University of South California have discovered the mechanism.

The single RNA binding protein (named MSI-2) helps to accumulate multiple cancer-causing proteins in patients and helps to proliferate Hepatitis C Virus to promote liver cancer.

Siddique and the team who have identified this protein by analysing the liver tissues of 374 liver cancer patients, told IANS, “As we know, alcohol and cholesterol-rich high-fat diet and hepatitis infection promotes cancer initiation, but the exact molecular mechanism is unknown. In this research work, we have discovered that MSI-2 protein helps to accumulate multiple cancer-causing proteins and supports HCV proliferation to aggravate the disease.”

Dr Siddique said that Liver hyperplasia is also reduced in the animal model predisposed to viral infection fed with alcohol mixed cholesterol-rich high-fat diet. This is a very exciting discovery and could serve as a potential therapeutic target for the drug design and give direction to the management strategy for this deadly disease.

“The study has been recently published in Cell Death Discovery (April 2023, available at www.nature.com/cddiscovery),” he added.

Dr Siddique and his team had earlier discovered the molecular pathway that promotes the abnormal division of cancer stem cells that are responsible for cancer therapy failure and Cancer reappearance/recurrence. Their study was then published in the prestigious journal Nature Communications 11 (2020).

He said that the liver is considered the powerhouse of the body and due to the change in lifestyle, chronic alcohol consumption, high-fat diet, and hepatitis virus infection, the incidence of liver cancer is increasing fast.

More than 350 million people are currently infected with hepatitis viruses, out of which 70 million are infected with Hepatitis C. It is estimated that approximately 40 million people are chronically infected with Hepatitis B and 6-12 million people with Hepatitis C. The situation worsens when Hepatitis infection occurs in an alcoholic person.

He said that the discovery is significant in the treatment of liver cancer as blocking the identified protein has an immense effect on liver cancer in the animal model and also stops the accumulation of the number of human cancer-causing proteins, the proliferation of hepatitis viruses and improving recovery.

Siddique recently got a patent for his herbal formulation to prevent liver cancer and expecting some extramural grant from the Government of India for further clinical research.

–IANS

amita/svn/

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

History
First published on:

Disclaimer
Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can further read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

More in

Questions
Fact Check
Interviews
Stories
Videos

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

More in

Questions
Fact Check
Interviews
Stories
Videos

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

Last Updated on May 3, 2023 by Team THIP

Disclaimer: Medical Science is an ever evolving field. We strive to keep this page updated. In case you notice any discrepancy in the content, please inform us at [email protected]. You can futher read our Correction Policy here. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website or it's social media channels. Read our Full Disclaimer Here for further information.

- Advertisement -spot_img
Read More